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Free practice question: Painless injuries with absent smell

Question 14 of 25 in the free Starter set. Single best answer, three options, like the real exam.

G1a · Anatomy, physiology and pharmacology of nociception

A 9-year-old boy is referred after several painless fractures and a hand burn he did not notice. He sweats normally, has normal intelligence, normal light-touch and vibration sense, and normal nerve conduction studies. His parents, who are first cousins, add that he has never been able to smell food or smoke. Which molecular defect best explains this presentation?

Review the topic: Pain genetics: sodium channelopathies and opioid pharmacogenetics · Pain neurobiology: nociceptors, channels and central sensitization

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